1443008-01-2

Upstream product

• 1443008-06-7 (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide 
• 1443008-05-6 (R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide 
• 550-58-3 (1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol 
• 100-51-6 benzyl alcohol 
• 1443008-03-4 tert-butyl ((R)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate 
• 15082-42-5 lithium benzyloxide 
• 1443008-27-2 C₂₆H₃₄N₂O₂ 
• 1443008-15-8 (S)-2-amino-3-cyclohexyl-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethylpropanamide 
• 1443008-10-3 (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide 
• 1443007-95-1 (S)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide 
• 1443007-93-9 (R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide 
• 1443008-04-5 tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate 

Downstream Products

• 1443008-04-5 tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate 
• 1443007-93-9 (R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide 
• 1443007-95-1 (S)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide 
• 1443008-10-3 (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide 
• 1443008-35-2 (R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide 
• 1443008-11-4 (S)-tert-butyl 3-amino-4-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-3-methyl-4-oxobutanoate 
• 1443008-12-5 (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethylbutanamide 
• 1443008-38-5 (R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethylbutanamide 
• 1443008-13-6 (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-3-(3-methoxyphenyl)-N,2-dimethylpropanamide 
• 1443008-14-7 (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2,4-trimethylpentanamide 
• 1443008-15-8 (S)-2-amino-3-cyclohexyl-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethylpropanamide 
• 1443008-03-4 tert-butyl ((R)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate 
• 1443007-97-3 (S)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethylpyrrolidine-2-carboxamide 
• 1443008-16-9 C₂₂H₂₈N₂O₂ 

Relevant academic research and scientific papers

Synthesis of quaternary α-methyl α-amino acids by asymmetric alkylation of pseudoephenamine alaninamide pivaldimine

The utility of pseudoephenamine as a chiral auxiliary for the alkylative construction of quaternary α-methyl α-amino acids is demonstrated. The method is notable for the high diastereoselectivities of the alkylation reactions, for its versatility with respect to electrophilic substrate partners, and for its mild hydrolysis conditions, which provide α-amino acids without salt contaminants. Alternatively, α-amino esters can be obtained by direct alcoholysis.