1443124-69-3

Basic information

• Product Name: (±)-4-amino-N-p-tolylcyclopent-1-enecarboxamide
• CAS NO: 1443124-69-3
• Molecular Weight: 216.283
• Mol File: 1443124-69-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (±)-4-amino-N-p-tolylcyclopent-1-enecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-4-amino-N-p-tolylcyclopent-1-enecarboxamide(1443124-69-3)
• EPA Substance Registry System: (±)-4-amino-N-p-tolylcyclopent-1-enecarboxamide(1443124-69-3)

Safety Data

• Hazardous Substances Data: 1443124-69-3(Hazardous Substances Data)

Upstream product

• 1060803-66-8 (+/-)-cis-Methyl-4-tert-butoxycarbonylaminocyclopent-2-en-1-carboxylate 
• 426226-35-9 methyl 4-aminocyclopent-2-ene-1-carboxylate Hydrochloride 
• 49805-30-3 racemic 2-azabicyclo[2.2.1]hept-5-en-3-one 
• 1358799-04-8 (±)-4-(tert-butoxycarbonylamino)cyclopent-1-enecarboxylic acid 
• 1169936-04-2 (±)-methyl 4-(tert-butoxycarbonylamino)cyclopent-1-enecarboxylate 

Relevant articles and documents

γ-Aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: Amides and hydroxamates

Series of compounds were generated via the bioisosteric replacement of the carboxylate of 4-ACPCA (2) with hydroxamate or amide groups. All compounds from this study exhibited increased selectivity for GABAC, the most potent being 4-ACPHA (10a, IC50 = 13 μM) and 4-ACPAM (11a, IC 50 = 10 μM). This provides evidence that a zwitterionic structure is not essential for GABAC antagonists, rather the emphasis lies in appropriate heteroatoms to participate in hydrogen bonding.