1443129-39-2

Upstream product

• 1694-31-1 tert-butyl acetoacetate 
• 696602-10-5 3-chloro-1-(4-cyanophenyl)-1-propene 

Downstream Products

• 1443129-01-8 tert-butyl (1S,2S,3R)-2-(4-cyanophenyl)bicyclo[1.1.0]butane-1-carboxylate 
• 1443128-89-9 tert-butyl (E)-5-(4-cyanophenyl)-2-diazopent-4-enoate 

Relevant academic research and scientific papers

Enantioselective synthesis of cyclobutanes via sequential Rh-catalyzed bicyclobutanation/Cu-catalyzed homoconjugate addition

Enantiomerically enriched cyclobutanes are constructed by a three-component process in which t-butyl (E)-2-diazo-5-arylpent-4-enoates are treated with Rh2(S-NTTL)4 to provide enantiomerically enriched bicyclobutanes, which can subsequently engage in homoconjugate addition/enolate trapping sequence to give densely functionalized cyclobutanes with high diastereoselectivity. This three-component, two-catalyst procedure can be carried out in a single flask. Rh2(S-NTTL)4-catalyzed reaction of t-butyl (Z)-2-diazo-5-phenylpent-4-enoate gives the Buechner cyclization product in excellent enantioselectivity.