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1443129-95-0

ethyl 2-(2-(cyclohexanecarbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1443129-95-0 Structure

  • Basic information

    1. Product Name: ethyl 2-(2-(cyclohexanecarbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate
    2. Synonyms:
    3. CAS NO:1443129-95-0
    4. Molecular Formula:
    5. Molecular Weight: 368.476
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1443129-95-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 2-(2-(cyclohexanecarbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 2-(2-(cyclohexanecarbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate(1443129-95-0)
    11. EPA Substance Registry System: ethyl 2-(2-(cyclohexanecarbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate(1443129-95-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1443129-95-0(Hazardous Substances Data)

1443129-95-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1443129-95-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,3,1,2 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1443129-95:
(9*1)+(8*4)+(7*4)+(6*3)+(5*1)+(4*2)+(3*9)+(2*9)+(1*5)=150
150 % 10 = 0
So 1443129-95-0 is a valid CAS Registry Number.

1443129-95-0Downstream Products

1443129-95-0Relevant articles and documents

Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1 H-pyrido[4,3-b ]indol-5(2 H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist

Fretz, Heinz,Valdenaire, Anja,Pothier, Julien,Hilpert, Kurt,Gnerre, Carmela,Peter, Oliver,Leroy, Xavier,Riederer, Markus A.

, p. 4899 - 4911 (2013)

Herein we describe the discovery of the novel CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid 28 (setipiprant/ACT-129968), a clinical development candidate for the treatment of asthma and seasonal allergic rhinitis. A lead optimization program was started based on the discovery of the recently disclosed CRTh2 antagonist 2-(2-benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid 5. An already favorable and druglike profile could be assessed for lead compound 5. Therefore, the lead optimization program mainly focused on the improvement in potency and oral bioavailability. Data of newly synthesized analogs were collected from in vitro pharmacological, physicochemical, in vitro ADME, and in vivo pharmacokinetic studies in the rat and the dog. The data were then analyzed using a traffic light selection tool as a visualization device in order to evaluate and prioritize candidates displaying a balanced overall profile. This data-driven process and the excellent results of the PK study in the rat (F = 44%) and the dog (F = 55%) facilitated the identification of 28 as a potent (IC50 = 6 nM), selective, and orally available CRTh2 antagonist.

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