1443134-15-3

Basic information

• Product Name: 4',5,6,7,8-pentamethoxy-2-flavene
• Synonyms: 4',5,6,7,8-pentamethoxy-2-flavene
• CAS NO: 1443134-15-3
• Molecular Weight: 358.391
• Mol File: 1443134-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4',5,6,7,8-pentamethoxy-2-flavene(CAS DataBase Reference)
• NIST Chemistry Reference: 4',5,6,7,8-pentamethoxy-2-flavene(1443134-15-3)
• EPA Substance Registry System: 4',5,6,7,8-pentamethoxy-2-flavene(1443134-15-3)

Safety Data

• Hazardous Substances Data: 1443134-15-3(Hazardous Substances Data)

Upstream product

• 481-53-8 tangeritin 

Relevant articles and documents

Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors

In a continuing study for discovering urease inhibitors based on flavonoids, nineteen reductive derivatives of flavonoids were synthesized and evaluated against Helicobacter pylori urease. Analysis of structure-activity relationship disclosed that 4-deoxy analogues are more potent than other reductive products. Out of them, 4′,7,8-trihydroxyl-2-isoflavene (13) was found to be the most active with IC50 of 0.85 μM, being over 20-fold more potent than the commercial available urease inhibitor, acetohydroxamic acid (AHA). Kinetics study revealed that 13 is a competitive inhibitor of H. pylori urease with a Ki value of 0.641 μM, which is well matched with the results of molecular docking. Biological evaluation and mechanism study of 13 suggest that it is a good candidate for discovering novel anti-gastritis and anti-gastric ulcer agent.