144314-68-1Relevant articles and documents
A brief total synthesis of Pyrrolostatin
Dunford, Damian G.,Knight, David W.
, p. 2746 - 2748 (2016)
A novel total synthesis of the unusual naturally occurring 2,4-disubstituted pyrrole, Pyrrolostatin 1, is described, which features formation of the central pyrrole ring by a recently developed silver(I)-catalysed 5-endo-dig cyclisation.
Short and highly efficient synthesis of lipid peroxidation inhibitor pyrrolostatin and some analogues thereof
Schmidt, Jens,Adrian, Juliane,Stark, Christian B.W.
, p. 8173 - 8176 (2015/08/03)
A highly efficient and scalable synthesis of potent lipid peroxidation inhibitor pyrrolostatin is reported (4 steps, 48%). In addition to the synthesis of the natural product, strategies for the preparation of analogues differing in the three structural subunits, the polar head group, the N-substituent and the lipophilic tail are described.
