1443147-47-4Relevant academic research and scientific papers
Pd-catalyzed asymmetric allylic alkylation of pyrazol-5-ones with allylic alcohols: The role of the chiral phosphoric acid in C-O bond cleavage and stereocontrol
Tao, Zhong-Lin,Zhang, Wen-Quan,Chen, Dian-Feng,Adele, Arafate,Gong, Liu-Zhu
, p. 9255 - 9258 (2013)
The combination of a palladium complex with a chiral phosphoramidite ligand and a chiral phosphoric acid enables the first highly efficient asymmetric allylic alkylation of pyrazol-5-ones with allylic alcohols, affording multiply functionalized heterocyclic products in high yields with excellent enantioselectivities that would be of great potential in the synthesis of pharmaceutically interesting molecules.
