1443150-74-0

Basic information

• Product Name: N-{[3-(trifluoromethyl)phenyl]thio}phthalimide
• Synonyms: N-{[3-(trifluoromethyl)phenyl]thio}phthalimide
• CAS NO: 1443150-74-0
• Molecular Weight: 323.295
• Mol File: 1443150-74-0.mol

Chemical Properties

• CAS DataBase Reference: N-{[3-(trifluoromethyl)phenyl]thio}phthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{[3-(trifluoromethyl)phenyl]thio}phthalimide(1443150-74-0)
• EPA Substance Registry System: N-{[3-(trifluoromethyl)phenyl]thio}phthalimide(1443150-74-0)

Safety Data

• Hazardous Substances Data: 1443150-74-0(Hazardous Substances Data)

Upstream product

• 54974-07-1 phthalimidesulfenyl chloride 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 7764-30-9 2,2'-disulfanediylbis(isoindoline-1,3-dione) 
• 136918-14-4 phthalimide 

Downstream Products

• 32466-24-3 1-(Fluorsulfonyl)-3-(trifluormethyl)benzol 
• 1443150-81-9 C₂₁H₁₉F₃O₃S 

Relevant articles and documents

A Unified Strategy for Arylsulfur(VI) Fluorides from Aryl Halides: Access to Ar-SOF3 Compounds

A convenient protocol to selectively access various arylsulfur(VI) fluorides from commercially available aryl halides in a divergent fashion is presented. Firstly, a novel sulfenylation reaction with the electrophilic N-(chlorothio)phthalimide (Cl-S-Phth) and arylzinc reagents afforded the corresponding Ar-S-Phth compounds. Subsequently, the S(II) atom was selectively oxidized to distinct fluorinated sulfur(VI) compounds under mild conditions. Slight modifications on the oxidation protocol permit the chemoselective installation of 1, 3, or 4 fluorine atoms at the S(VI) center, affording the corresponding Ar-SO2F, Ar-SOF3, and Ar-SF4Cl. Of notice, this strategy enables the effective introduction of the rare and underexplored -SOF3 moiety into various (hetero)aryl groups. Reactivity studies demonstrate that such elusive Ar-SOF3 can be utilized as a linchpin for the synthesis of highly coveted aryl sulfonimidoyl fluorides (Ar-SO(NR)F).