14432-13-4

Basic information

• Product Name: 2-CHLORO-4-N-NITRO(AMINOPYRIDINE)
• Synonyms: 2-CHLORO-4-N-NITRO(AMINOPYRIDINE);2-chloro-N-nitropyridin-4-aMine
• CAS NO: 14432-13-4
• Molecular Formula: C₅H₄ClN₃O₂
• Molecular Weight: 173.56
• Mol File: 14432-13-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 148 °C (decomp)
• Boiling Point: 317.4 °C at 760 mmHg
• Flash Point: 145.8 °C
• Appearance: /
• Density: 1.573 g/cm³
• PKA: 4.89±0.30(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-N-NITRO(AMINOPYRIDINE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-N-NITRO(AMINOPYRIDINE)(14432-13-4)
• EPA Substance Registry System: 2-CHLORO-4-N-NITRO(AMINOPYRIDINE)(14432-13-4)

Safety Data

• Hazardous Substances Data: 14432-13-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-nitroaniline (4-chloro-2-nitroaniline) is an organic compound that consists of a chlorinated aniline with a nitro functional group. It is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. 2-Chloro-4-nitroaniline is a yellow crystalline solid that is sparingly soluble in water and is known to be toxic if ingested or inhaled. It is also considered harmful to aquatic life and the environment and should be handled with caution.

Upstream product

• 19798-80-2 2-Amino-4-chloropyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 2604-39-9 4-amino-2-chloro-5-nitropyridine 
• 2789-25-5 2-chloro-3-nitropyridin-4-amine 
• 877651-81-5 1-[(1R,4R,5S)-3-(trityloxymethyl)-4,5-O-iso-propylidinene-2-cyclopenten-1-yl]-4-chloroimidazo[4,5-c]pyridine 
• 877651-87-1 4-chloro-3-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-3H-imidazo[4,5-c]pyridine 
• 1207615-07-3 7H-imidazo[4,5-c]tetrazo[1,5-a]pyridine 

Relevant articles and documents

L-deaza-5'-noraisteromycin.

(+/-)-1-Deazaaristeromycin (4) has been reported to be an inactivator of S-adenosylhomocysteine (AdoHcy) hydrolase and, as a consequence, to affect S-adenosylmethionine (AdoMet) mediated macromolecular biomethylations. To extend this to our program focused on 5'-noraristeromycin derivatives as inhibitors of the same hydrolase enzyme as potential antiviral agents, both enantiomers of 1-deaza-5'-noraristeromycin (5 and 20) have been prepared. Compounds 5 and 20 were evaluated against the following viruses: vaccinia, cowpox, monkeypox, Ebola, herpes simplex type 1 and 2, human cytomegalovirus, Epstein Barr, varicella zoster, hepatitis B, hepatitis C, HIV-1 and HIV-2, adenovirus type 1, measles, Pichinde, parainfluenza type 3, influenza A (H1N1 and H3N2), influenza B, Venezuelan equine encephalitis, rhinovirus type 2, respiratory syncytial, yellow fever, and West Nile. No activity was found nor was there any cytotoxicity to the viral host cells.

Thiophene-imidazopyridines

The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1

MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.