1443209-74-2Relevant academic research and scientific papers
Enzyme-labile protecting groups for the synthesis of natural products: Solid-phase synthesis of thiocoraline
Tulla-Puche, Judit,G?ngora-Benítez, Miriam,Bay?-Puxan, Núria,Francesch, Andrés M.,Cuevas, Carmen,Albericio, Fernando
, p. 5726 - 5730 (2013)
Another (orthogonal) dimension: The solid-phase synthesis of thiocoraline was accomplished for the first time by a combined approach involving chemical and enzymatic methods. One-pot cleavage of the phenylacetamidomethyl protecting group using immobilized penicillinG acylase enzyme (see picture) and disulfide formation are the key steps of the synthetic strategy. Copyright
