1443216-77-0

Basic information

• Product Name: C₁₈H₂₆N₆O₂
• Synonyms: C₁₈H₂₆N₆O₂
• CAS NO: 1443216-77-0
• Molecular Weight: 358.443
• Mol File: 1443216-77-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₆N₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₆N₆O₂(1443216-77-0)
• EPA Substance Registry System: C₁₈H₂₆N₆O₂(1443216-77-0)

Safety Data

• Hazardous Substances Data: 1443216-77-0(Hazardous Substances Data)

Upstream product

• 454709-07-0 8-bromo-1,3-dimethyl-7-(3-methyl-but-2-enyl)-3,7-dihydro-purine-2,6-dione 
• 185693-02-1 hexahydropyrrolo[3,4-b]pyrrole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Integrated synthesis and testing of substituted xanthine based DPP4 inhibitors: Application to drug discovery

A novel integrated discovery platform has been used to synthesize and biologically assay a series of xanthine-derived dipeptidyl peptidase 4 (DPP4) antagonists. Design, synthesis, purification, quantitation, dilution, and bioassay have all been fully integrated to allow continuous automated operation. The system has been validated against a set of known DPP4 inhibitors and shown to give excellent correlation between traditional medicinal chemistry generated biological data and platform data. Each iterative loop of synthesis through biological assay took two hours in total, demonstrating rapid iterative structure-activity relationship generation.