1443223-40-2Relevant academic research and scientific papers
PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS
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Paragraph 0173; 0201-0209; 0273-0281, (2015/06/24)
The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.
Direct copper-catalyzed α-arylation of benzyl phenyl ketones with aryl iodides: Route towards tamoxifen
Danoun, Grégory,Tlili, Anis,Monnier, Florian,Taillefer, Marc
supporting information, p. 12815 - 12819 (2013/02/22)
No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for the management of breast cancer. R, R′, R′′ = electron-donating or electron-withdrawing groups. Copyright
