1443237-67-9

Upstream product

• 13331-27-6 m-nitrobenzene boronic acid 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 1443237-66-8 5-bromo-4-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1443237-65-7 4-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 1443237-01-1 N-(3-(5-[4-(aminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-methylprop-2-enamide 
• 1443237-68-0 tert-butyl 5-bromo-4-{3-[(tert-butoxycarbonyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate 

Relevant academic research and scientific papers

Highly selective Janus kinase 3 inhibitors based on a pyrrolo[2,3-d] pyrimidine scaffold: Evaluation of WO2013085802

A series of pyrrolo[2,3-d]pyrimidine derivatives have previously been claimed as Janus kinase (JAK) 1 selective inhibitors. Introduction of a 4-aryl substituent onto this bicyclic scaffold modulates the JAK selectivity profile, thus providing JAK3 selective inhibitors. This patent application claims such compounds as JAK3 inhibitors. Many of the compounds exemplified show > 100,000-fold selectivity for JAK3 over JAK2. The inhibitors are claimed to be useful in the treatment of respiratory diseases, arthritis and cancer.

PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such