1443293-76-2

Upstream product

• 1443293-87-5 (±)-2-(4-iodophenyl)-1,4-dioxaspiro[4.5]deca-6,9-dien-8-one 
• 63503-60-6 3-chlorophenylboronic acid 
• 935-50-2 4,4-dimethoxycyclohexa-2,5-dienone 
• 1426913-89-4 1-(4-iodophenyl)ethane-1,2-diol 

Relevant academic research and scientific papers

Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-onesas potential anticancer agents starting from cytotoxic spiromamakone A

The spirocycle is a key structure found in many bioactive compounds. From the cytotoxic and spirocyclic natural product, spiromamakone A (1) and its analogues, a more synthetically accessible spiroacetal template 4 was designed based on structural similarity analysis. A total of 50 compounds were rapidly synthesized in only one or two synthetic steps from the starting compound, and their cytotoxicity was evaluated. As a result, (±)-(2R*,5R*)- 2-(4-iodophenyl)-7-chloro-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-one (7d-II) was discovered and found to be fifteen-fold more cytotoxic than 1. The easily accessible spiroacetal 7d-II appeared to act in a manner similar to the highly oxidized natural product, spiromamakone A (1).