144331-21-5Relevant articles and documents
Stereospecific synthesis of (2S,4R)-[5,5,5-2H3]leucine
August, Ryan A.,Khan, Jeffrey A.,Moody, Claire M.,Young, Douglas W.
, p. 507 - 514 (1996)
The first stereospecific chemical synthesis of a sample of the amino acid (2S)-leucine labelled in one of the diastereotopic methyl groups has been achieved using (2S)-pyroglutamic acid as a chiral template. This has been used to develop a method for assigning resonances to the diastereotopic methyl groups of the leucine residues in the 1H NMR spectra of proteins.
L-Y-METHYLENEGLUTAMINE COMPOUNDS AND METHODS OF USE
-
Paragraph 0088-0091, (2021/02/12)
Disclosed are substantially pure L-y-methyleneglutamine, L-y- methyleneglutamic acid, and/or amide derivatives, and methods of use thereof. In particular, the presently disclosed subject matter relates to L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives thereof, and methods of treating cancer. The method comprises administering one or more substantially pure L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives to a subject in need thereof.
Stereospecific Synthesis of (2S,4R)--Leucine
August, Ryan A.,Khan, Jeffrey A.,Moody, Claire M.,Young, Douglas W.
, p. 4617 - 4620 (2007/10/02)
The first fully stereospecific synthesis of a sample of the amino acid (2S)-leucine labelled in only one of the diastereotopic methyl groups has been achieved using (2S)-pyroglutamic acid as a chiral template. Key Words: leucine; stereospecific synthesis; amino acid; isotopic labelling; bio-organic
