144332-75-2

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 38065-38-2 (4-bromophenyl)methyl 4-nitrophenyl carbonate 
• 144332-74-1 (S)-1-(4-bromobenzyl)2-methyl pyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1609689-86-2 (S)-(4’-isopropyl-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-85-1 (S)-(3’-isopropyl-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-84-0 (S)-(4’-ethyl-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-83-9 (S)-(4’-methyl-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate 
• 1609689-82-8 (S)-(3’-methyl-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-81-7 (S)-[1,1’-biphenyl]-4-ylmethyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate 
• 1609689-78-2 (S)-4-bromobenzyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate 
• 1609690-05-2 (S)-4-(6-chloropyridin-3-yl)benzyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate 
• 1609690-04-1 (S)-4-(5-chloropyridin-3-yl)benzyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate 
• 1609690-03-0 (S)-(3’-isopropoxy-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609690-02-9 (S)-(3’-ethoxy-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609690-01-8 (S)-(3’-methoxy-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609690-00-7 (S)-(4’-methoxy-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 
• 1609689-99-7 (S)-(4’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)methyl 2-(((S)-3-amino-1-cyano-3-oxopropyl)carbamoyl)-pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

This Letter describes the further development and SAR exploration of a novel series of Legumain inhibitors. Based upon a previously identified Legumain inhibitor from our group, we explored the SAR of the carbamate phenyl ring system to probe the P3 pocke

SYNTHESIS AND SOLUTION CONFORMATIONAL ANALYSIS OF β-BEND RIBBON FORMING PEPTIDES

The synthesis and characterization of three long, complete, terminally blocked -(L-Pro-Aib)n- and -Aib-(L-Pro-Aib)n- sequential peptide series (from di- to decapeptides), representing potential model compounds for the β-bend ribbon spiral, are reported.A