1443382-52-2

Basic information

• Product Name: C₁₉H₁₇N₃O₂
• CAS NO: 1443382-52-2
• Molecular Weight: 319.363
• Mol File: 1443382-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₇N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₇N₃O₂(1443382-52-2)
• EPA Substance Registry System: C₁₉H₁₇N₃O₂(1443382-52-2)

Safety Data

• Hazardous Substances Data: 1443382-52-2(Hazardous Substances Data)

Upstream product

• 876733-11-8 6-methoxyindole 
• 145692-57-5 6-methoxyindole-3-carbonitrile 
• 3189-13-7 6-methoxylindole 
• 1443382-61-3 C₁₂H₁₃BN₂O₃ 

Relevant articles and documents

Discovery of N-(4′-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication

A series of novel 2-phenylindole analogs were synthesized and evaluated for activity in subgenomic HCV replicon inhibition assays. Several compounds containing small alkyl sulfonamides on the phenyl ring exhibiting submicromolar EC50 values against the genotype 1b replicon were identified. Among these, compound 25d potently inhibited the 1b replicon (EC50 = 0.17 μM) with 147-fold selectivity with respect to cytotoxicity. Compound 25d was stable in the presence of human liver microsomes and had a good pharmacokinetic profile in rats with an IV half-life of 4.3 h and oral bioavailability (F) of 58%.