1443383-33-2Relevant academic research and scientific papers
Auxiliary-enabled Pd-catalyzed direct arylation of methylene C(sp 3)-H bond of cyclopropanes: Highly diastereoselective assembling of Di- and trisubstituted cyclopropanecarboxamides
Parella, Ramarao,Gopalakrishnan, Bojan,Babu, Srinivasarao Arulananda
, p. 3238 - 3241 (2013/07/26)
An auxiliary-enabled and Pd(OAc)2-catalyzed direct arylation of C(sp3)-H bonds of cyclopropanes and production of di- and trisubstituted cyclopropanecarboxamides having contiguous stereocenters are reported. The installation of aryl groups on cyclopropanecarboxamides led to the assembling of novel mono- and di- aryl-N-(quinolin-8-yl)cyclopropanecarboxamide scaffolds and mono- and di- aryl-N-(2-(methylthio)phenyl) cyclopropanecarboxamides. The stereochemistry of products was unequivocally assigned from the X-ray structures of key compounds.
