1443438-82-1

Basic information

• Product Name: 3-hydroxy-3-{5-[(E)-2-phenyl-1-ethenyl]-1,3,4-oxadiazol-2-yl}-2-butanone
• Synonyms: 3-hydroxy-3-{5-[(E)-2-phenyl-1-ethenyl]-1,3,4-oxadiazol-2-yl}-2-butanone
• CAS NO: 1443438-82-1
• Molecular Weight: 258.277
• Mol File: 1443438-82-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-{5-[(E)-2-phenyl-1-ethenyl]-1,3,4-oxadiazol-2-yl}-2-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-{5-[(E)-2-phenyl-1-ethenyl]-1,3,4-oxadiazol-2-yl}-2-butanone(1443438-82-1)
• EPA Substance Registry System: 3-hydroxy-3-{5-[(E)-2-phenyl-1-ethenyl]-1,3,4-oxadiazol-2-yl}-2-butanone(1443438-82-1)

Safety Data

• Hazardous Substances Data: 1443438-82-1(Hazardous Substances Data)

Upstream product

• 140-10-3 (E)-3-phenylacrylic acid 
• 73789-56-7 N-isocyaniminotriphenylphosphorane 
• 431-03-8 dimethylglyoxal 

Relevant articles and documents

The reaction of N -isocyaniminotriphenylphosphorane with biacetyl in the presence of (E) -cinnamic acids: Synthesis of fully substituted 1,3,4-oxadiazole derivatives via intramolecular aza -wittig reactions of in situ generated iminophosphoranes

Reaction of N-isocyaniminotriphenylphosphorane with biacetyl in the presence of (E)-cinnamic acids proceeds smoothly at room temperature and under neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction

Ultrasound-Promoted Three-Component Reaction of N -isocyaniminotriphenyl-phosphorane, (E)-cinnamic Acids, and Biacetyl

Fully substituted 1,3,4-oxadiazole derivatives were obtained in a one-pot three-component reaction of N-isocyaniminotriphenylphosphorane, biacetyl, and (E)-cinnamic acids in dichloromethane under ultrasound irradiation. This rapid method produced the products in short reaction times (16-27 min) and excellent yields (91-97%). GRAPHICAL ABSTRACT.