1443441-77-7Relevant academic research and scientific papers
Method for preparing furan compound from brominated arone
-
Page/Page column 7, (2021/06/13)
The invention provides a method for synthesizing a furan compound by taking brominated arone and methyl ketone or cyclic ketone as raw materials and directly reacting under the action of tetraisopropyl titanate. The method comprises the following steps: under the protection of inert gas, stirring and heating a reaction mixture of methyl ketone or cyclic ketone and bromo-arone, and then adding tetraisopropyl titanate for reaction; and after the reaction is finished, separating and purifying the obtained reaction mixture to obtain the polysubstituted furan compound. The synthesis method provided by the invention has the advantages of easily available raw materials, low cost, simple operation and easy control, no solvent, good substrate universality and functional group compatibility, and is suitable for industrial mass production.
Ruthenium(ii)-catalyzed chemoselective deacylative annulation of 1,3-diones with sulfoxonium ylides: Via C-C bond activation
Wen, Si,Lv, Weiwei,Ba, Dan,Liu, Jing,Cheng, Guolin
, p. 9104 - 9108 (2019/10/21)
The first successful example of deacylative annulation of 1,3-diones with sulfoxonium ylides was achieved through Ru(ii)-catalyzed C-C bond activation. The excellent chemoselectivity and broad substrate scope render this method a practical and versatile approach for the preparation of (hetero)aryl and alkenyl substituted furans, which are valuable units in many biologically active compounds and functional materials. A preliminary mechanistic study reveals that this process involves a deacylative α-ruthenation to generate key alkyl Ru(ii) intermediates with the release of a benzoic acid fragment.
Aerobic oxidative α-arylation of furans with boronic acids via Pd(II)-catalyzed C-C bond cleavage of primary furfuryl alcohols: Sustainable access to arylfurans
Huang, Guanghao,Lu, Lin,Jiang, Huanfeng,Yin, Biaolin
supporting information, p. 12217 - 12220 (2017/11/16)
Aerobic oxidative α-arylation of furans with boronic acids via Pd(ii)-catalyzed C-C bond cleavage of primary furfuryl alcohols provides sustainable access to arylfurans. This protocol opens a new avenue for the transformation of readily available furans into other useful compounds.
[4 + 2] Annulation of Donor-Acceptor Cyclopropanes with Acetylenes Using 1,2-Zwitterionic Reactivity
Novikov, Roman A.,Tarasova, Anna V.,Denisov, Dmitry A.,Borisov, Denis D.,Korolev, Victor A.,Timofeev, Vladimir P.,Tomilov, Yury V.
, p. 2724 - 2738 (2017/03/14)
A new process for the [4 + 2] annulation of donor-acceptor cyclopropanes with acetylenes under the effect of anhydrous GaCl3 using 1,2-zwitterion reactivity was elaborated. The reaction opens access to substituted dihydronaphthalenes, naphthalenes, and other fused carbocycles. The direction of the reaction can be efficiently controlled by temperature.
Synthesis of polysubstituted furans via copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids
Yang, Yuzhu,Yao, Jinzhong,Zhang, Yuhong
supporting information, p. 3206 - 3209 (2013/07/26)
A novel copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids has been accomplished. This reaction provides a facile and regio-defined method for the synthesis of 2,3,5-trisubstituted furans from simple chemical reagents.
