1443442-38-3

Basic information

• Product Name: 5-benzyl-6-(2-chlorophenyl)-8-(4-fluorophenyl)indolizine
• Synonyms: 5-benzyl-6-(2-chlorophenyl)-8-(4-fluorophenyl)indolizine
• CAS NO: 1443442-38-3
• Molecular Weight: 411.906
• Mol File: 1443442-38-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-benzyl-6-(2-chlorophenyl)-8-(4-fluorophenyl)indolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyl-6-(2-chlorophenyl)-8-(4-fluorophenyl)indolizine(1443442-38-3)
• EPA Substance Registry System: 5-benzyl-6-(2-chlorophenyl)-8-(4-fluorophenyl)indolizine(1443442-38-3)

Safety Data

• Hazardous Substances Data: 1443442-38-3(Hazardous Substances Data)

Upstream product

• 55379-75-4 2-amino-3-phenylpropanenitrile 
• 28081-11-0 3-(2-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one 
• 1443442-27-0 3-phenyl-2-(1H-pyrrol-1-yl)propanenitrile 

Relevant articles and documents

One-pot synthesis of polysubstituted indolizines by an addition/ cycloaromatization sequence

Indolizines carrying various substituents in positions 5-8 were obtained from readily available 2-(1H-pyrrol-1-yl)nitriles and α,β-unsaturated ketones or aldehydes in a one-pot procedure. Michael addition of the deprotonated aminonitriles to the acceptors followed by acid-catalyzed electrophilic cyclization produces 5,6-dihydroindolizine-5-carbonitriles. From these stable intermediates, substituted indolizines were obtained via base-induced dehydrocyanation.