1443461-21-9 Usage
Biological Activity
gsk2838232 is an hiv-1 maturation inhibitor [1] [2].hiv-1 maturation inhibitors disrupt the cleavage of the hiv-1 gag protein immediate precursor by the enzyme hiv-1 protease. maturation inhibitors bind the gag protein, which leads to the formation of immature, noninfectious virus particles incapable of infecting other cells. also, maturation inhibitors inhibit hiv infections with resistance.gsk2838232 is a hiv-1 maturation inhibitor and is active against a broad range of isolates, including those resistant to bevirimat [1]. gsk2838232 was developed for the treatment of chronic hiv infection. a phase i study in hiv-negative individuals had been completed. single doses of 5, 10 or 20 mg gsk2838232 were used to evaluate the initial safety, tolerability, pharmacokinetics profile, and the effects of food and ritonavir on gsk2838232’s bioavailability and pharmacokinetics [2].
references
[1]. olender sa, taylor bs, wong m, et al. croi 2015: advances in antiretroviral therapy. croi 2015 highlights: antiretroviral therapy volume 23 issue 1 march/april 2015.[2]. horn t, collins s. the antiretroviral pipeline. antiretrovirals, 2014 pipeline report.
Check Digit Verification of cas no
The CAS Registry Mumber 1443461-21-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,3,4,6 and 1 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1443461-21:
(9*1)+(8*4)+(7*4)+(6*3)+(5*4)+(4*6)+(3*1)+(2*2)+(1*1)=139
139 % 10 = 9
So 1443461-21-9 is a valid CAS Registry Number.
1443461-21-9Relevant articles and documents
DERIVATIVES OF BETULIN
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Paragraph 00273, (2013/07/05)
The present invention relates to compounds characterized by having a structure according to the following Formula I: (I), or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.
