Cas 1443511-08-7,4β-N-[2'',3''-bis(tert-butoxycarbonylamino)propanoyl]-4'-O-demethyl-podophyllotoxin

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Check Digit Verification of cas no

The CAS Registry Mumber 1443511-08-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,3,5,1 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1443511-08:
(9*1)+(8*4)+(7*4)+(6*3)+(5*5)+(4*1)+(3*1)+(2*0)+(1*8)=127
127 % 10 = 7
So 1443511-08-7 is a valid CAS Registry Number.

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1443511-08-7Relevant academic research and scientific papers

Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin

Liu, Xuan,Zhang, Lin-Lin,Xu, Xiao-Hui,Hui, Lin,Zhang, Jin-Bang,Chen, Shi-Wu

supporting information, p. 3780 - 3784 (2013/07/27)

A series of dichloroplatinum(II) complexes of podophyllotoxin (PPT) were prepared, and their cytotoxicity against sensitive (A-549, HeLa, HCT-8, Hep-G2, K562) and resistant (ADM/K562) cell lines were evaluated. Complex cis-[4α-O-(2″,3″-diaminopropanoyl)-podophyllotoxin] dichloride platinum(II) (12) displayed most potent cytotoxicity with IC50 value in the range 0.071-2.98 μM. Complex 12 induces cell cycle arrest in the G2/M phase, and inhibits the formation of microtubules in HeLa cells. Furthermore, this complex exhibits potent DNA cleavage capabilities.

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