1443529-63-2

Upstream product

• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 
• 286454-86-2 (S)‐1‐(diphenylphosphino)‐3,3‐dimethylbutan‐2‐amine 

Downstream Products

• 1443529-64-3 (S)-benzyl(2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-3,3-dimethylbutyl)diphenylphosphonium bromide 

Relevant academic research and scientific papers

Dual-reagent organophosphine catalyzed asymmetric Mannich reactions of isocyanoacetates with N-Boc-aldimines

A combination of an amino-acid derived chiral phosphine catalyst and methyl acrylate has been employed to catalyze the direct Mannich reaction of α-aryl isocyanoacetate and N-Boc-aldimines efficiently. The loading of the catalyst could be as low as 0.5 mol% without compromise on the yield and enantioselectivity and the corresponding chiral adducts were obtained in excellent yields (up to 98%) and good enantioselectivities (up to 95%).