1443533-79-6

Basic information

• Product Name: (1E,4E)-1-(benzylamino)-1-(methylthio)-5-(3,4,5-trimethoxyphenyl)-penta-1,4-dien-3-one
• Synonyms: (1E,4E)-1-(benzylamino)-1-(methylthio)-5-(3,4,5-trimethoxyphenyl)-penta-1,4-dien-3-one
• CAS NO: 1443533-79-6
• Molecular Weight: 399.511
• Mol File: 1443533-79-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1E,4E)-1-(benzylamino)-1-(methylthio)-5-(3,4,5-trimethoxyphenyl)-penta-1,4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,4E)-1-(benzylamino)-1-(methylthio)-5-(3,4,5-trimethoxyphenyl)-penta-1,4-dien-3-one(1443533-79-6)
• EPA Substance Registry System: (1E,4E)-1-(benzylamino)-1-(methylthio)-5-(3,4,5-trimethoxyphenyl)-penta-1,4-dien-3-one(1443533-79-6)

Safety Data

• Hazardous Substances Data: 1443533-79-6(Hazardous Substances Data)

Upstream product

• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 117672-15-8 (E)-1,1-bis (methylthio)-5-(3,4,5-trimethoxyphenyl)penta-1,4-dien-3-one 
• 100-46-9 benzylamine 

Relevant articles and documents

Synthesis and biological evaluation of a novel series of aryl S,N-ketene acetals as antileishmanial agents

A series of aryl S,N-ketene acetals 7(a-f) was synthesized and evaluated for their in vitro and in vivo antileishmanial activity against Leishmania donovani. All the 6 compounds exhibited significant in vitro activity against intracellular amastigotes of L. donovani with IC50 values ranging from 1.2 to 3.5 μM and were found promising as compared with reference drugs, sodium stibogluconate (SSG) and paromomycin. On the basis of good selectivity indices (SI), they were further tested for their in vivo potential against L. donovani/hamster model. Two compounds 7a and 7b showed significant inhibition of parasite multiplication, 72% and 83%, respectively. These compounds were comparable with SSG and superior to paromomycin. Preliminary in vitro metabolic investigations were also performed to assess the metabolic stability and in vitro hepatic intrinsic clearance (Clint) of compound 7b in hamster liver microsomes.