1443543-31-4

Basic information

• Product Name: C₂₃H₂₁ClN₂O
• Synonyms: C₂₃H₂₁ClN₂O
• CAS NO: 1443543-31-4
• Molecular Weight: 376.886
• Mol File: 1443543-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₁ClN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₁ClN₂O(1443543-31-4)
• EPA Substance Registry System: C₂₃H₂₁ClN₂O(1443543-31-4)

Safety Data

• Hazardous Substances Data: 1443543-31-4(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 50-84-0 2,4 dichlorobenzoic acid 
• 2038-57-5 3-Phenylpropan-1-amine 
• 86-38-4 6,9-dichloro-2-methoxyacridine 
• 91-38-3 4-chloro-2-(4-methoxyphenylamino)benzoic acid 

Relevant articles and documents

Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents

Acridine derivatives have been explored as DNA-binding anticancer agents. Some derivatives show undesired pharmacokinetic properties and new derivatives need to be explored. In this work, a series of novel acridine analogues were synthesized by modifying previously unexplored linkers between the acridine and benzene groups and their antiproliferative activity and the DNA-binding ability were evaluated. Among these derivatives, compound 5c demonstrated DNA-binding capability and topoisomerase I inhibitory activity. In K562 cell lines, 5c induced apoptosis through mitochondria-dependent intrinsic pathways. These data suggested that compound 5c and other acridine derivatives with modified linkers between the acridine and benzene groups might be potent DNA-binding agents.