1443545-68-3

Basic information

• Product Name: acetic acid (E)-2-acetoxy-5-(3-oxo-6-phenyl-hex-1-enyl)phenyl ester
• Synonyms: acetic acid (E)-2-acetoxy-5-(3-oxo-6-phenyl-hex-1-enyl)phenyl ester
• CAS NO: 1443545-68-3
• Molecular Weight: 366.414
• Mol File: 1443545-68-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetic acid (E)-2-acetoxy-5-(3-oxo-6-phenyl-hex-1-enyl)phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid (E)-2-acetoxy-5-(3-oxo-6-phenyl-hex-1-enyl)phenyl ester(1443545-68-3)
• EPA Substance Registry System: acetic acid (E)-2-acetoxy-5-(3-oxo-6-phenyl-hex-1-enyl)phenyl ester(1443545-68-3)

Safety Data

• Hazardous Substances Data: 1443545-68-3(Hazardous Substances Data)

Upstream product

• 133045-55-3 (E)-1-(3,4-dihydroxyphenyl)-6-phenyl-hex-1-en-3-one 
• 108-24-7 acetic anhydride 
• 2235-83-8 5-phenyl-2-pentanone 
• 10521-97-8 5-phenyl-pent-3-en-2-one 

Relevant articles and documents

Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation

E-3,4-Dihydroxy styryl aralkyl ketones as well as their 3,4-diacetylated derivatives as the analogues of neuroprotective agent CAPE were designed and synthesized for improving stability and lipid solubility. The neuroprotective activities of target compounds 10a-g and 11a-g were tested by three models in vitro, including 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity, neuronal protecting effect against damage induced by H2O2 in PC12 cells and nitric oxide suppression effect in BV2 microglial cells. The results demonstrated that compounds 10f and 11f exhibited the most potent neuroprotective effect against oxidative stress and inflammation, which is higher than that of the lead compound CAPE.