1443624-23-4

Basic information

• Product Name: (S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE
• Synonyms: (S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE;(2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HCl;Pyrrolidine, 2-(2,5-difluorophenyl)-, hydrochloride (1:1), (2S);(S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HCL;(2S)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride
• CAS NO: 1443624-23-4
• Molecular Formula: C10H12ClF2N
• Molecular Weight: 219.6587864
• Mol File: 1443624-23-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE(1443624-23-4)
• EPA Substance Registry System: (S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE(1443624-23-4)

Safety Data

• Hazardous Substances Data: 1443624-23-4(Hazardous Substances Data)

Usage

General Description

(S)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride is a chemical compound that is commonly used as a pharmaceutical intermediate in the production of various medications. It is a white to off-white crystalline powder that is soluble in water and ethanol. (S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE has a pyrrolidine ring structure and a difluorophenyl group, and is typically synthesized through chemical reactions involving pyrrolidine and difluorobenzene. It is often employed in the synthesis of selective serotonin reuptake inhibitors (SSRIs) and other psychoactive compounds due to its ability to modulate neurotransmitter activity in the brain, making it an important ingredient in the pharmaceutical industry.

Upstream product

• 871127-78-5 C₁₀H₈F₂O₃ 
• 540-36-3 para-difluorobenzene 
• 1443538-31-5 (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine 
• 1443538-30-4 (S,E)-N-(4-chloro-1-(2,5-difluorophenyl)butylidene)-2-methylpropane-2-sulfinamide 
• 1216260-42-2 4‐chloro‐1‐(2,5-difluorophenyl)butan-1-one 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 1218935-58-0 (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate 

Downstream Products

• 1443538-87-1 (R)-ethyl 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 1443538-88-2 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid 
• 1443536-91-1 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1443536-92-2 (R)-N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1443537-65-2 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1223404-89-4 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine 

Relevant articles and documents

Synthesis method of -2-(2, 5-difluorophenyl) pyrrolidine hydrochloride

The invention discloses a synthetic method of 2-(2, 5-difluorophenyl) pyrrolidine hydrochloride, which belongs to the field of drug synthesis. P-difluorobenzene and succinic anhydride are used as rawmaterials and subjected to a Friedel-Crafts reaction to obtain an intermediate I, the intermediate I is reduced to obtain an intermediate II, the intermediate II is subjected to an esterification reaction to obtain an intermediate III, and finally, the intermediate III is subjected to cyclization and salification under the action of liquid ammonia to obtain the 2-(2, 5-difluorophenyl) pyrrolidinehydrochloride. The method has the advantages of mild reaction conditions, cheap and easily available raw materials, high yield and good product purity.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.