1443675-28-2Relevant academic research and scientific papers
Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions
Foster, Robert S.,Adams, Harry,Jakobi, Harald,Harrity, Joseph P. A.
, p. 4049 - 4064 (2013/06/05)
We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.
