1443747-28-1

Basic information

• Product Name: C₁₇H₁₁ClFN₃O₃
• CAS NO: 1443747-28-1
• Molecular Weight: 359.744
• Mol File: 1443747-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₁ClFN₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₁ClFN₃O₃(1443747-28-1)
• EPA Substance Registry System: C₁₇H₁₁ClFN₃O₃(1443747-28-1)

Safety Data

• Hazardous Substances Data: 1443747-28-1(Hazardous Substances Data)

Upstream product

• 1252046-32-4 C₁₀H₇ClFN₃O₂ 
• 90-02-8 salicylaldehyde 
• 70458-93-4 7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester 
• 70032-30-3 diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate 
• 367-21-5 3-chloro-4-fluorophenylamine 

Relevant articles and documents

Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia

The mycobacterial Rv3097c-encoded lipase LipY is considered as a true lipase involved in the hydrolysis of triacylglycerol stored in lipid inclusion bodies for the survival of dormant mycobacteria. To date, orlistat is the only known LipY inhibitor. In view of the important emerging role of this enzyme, a search for small-molecule inhibitors of LipY was made, leading to the identification of some new compounds (8a-8d, 8f, 8h and 8i) with potent inhibitory activities against recombinant LipY, with no cytotoxicity [50% inhibitory concentration (CC50) ≥500 μg/mL]. The compounds 6a, 8c and 8f potently inhibited (>90%) the growth of Mycobacterium tuberculosis H37Rv grown under hypoxia (oxygen-depleted condition) but had no effect on aerobically grown bacilli, suggesting that these new small molecules are highly selective towards the growth inhibition of hypoxic cultures of M. tuberculosis and hence provide new leads for combating latent tuberculosis.