1443751-92-5Relevant academic research and scientific papers
Asymmetric synthesis of trifluoromethylated aziridines from CF 3-substituted N-tert-butanesulfinyl ketimines
Yang, Yanmei,Huang, Yangen,Qing, Feng-Ling
supporting information, p. 3826 - 3830 (2013/07/19)
A convenient and practical method for the asymmetric synthesis of trifluoromethylated aziridines was developed. The reactions of sulfur ylide with (S)-N-tert-butanesulfinyl ketimines gave trifluoromethylated aziridines 3 in moderate to excellent yields (45-93%) and good diastereoselectivities (86:14 to >99:1 dr). The synthetic application of these aziridines was examined through the acidic deprotection of the sulfinyl group and ring-opening reaction with dimethylsulfonium methylide to afford trifluoromethylated cyclopropylamine and α-trifluoromethylallylamine in 80% and 67% yields, respectively.
