144380-89-2Relevant academic research and scientific papers
Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine
Munoz, Lourdes,Rodriguez, Anna M.,Rosell, Gloria,Bosch, M. Pilar,Guerrero, Angel
, p. 8171 - 8177 (2011)
Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used. The Royal Society of Chemistry 2011.
SYNTHESIS, TAUTOMERIZATION AND ACYLATION OF 1-PHENYLPROPANE-2-IMINES
Zielinski, W.,Mazik, M.
, p. 661 - 668 (2007/10/02)
1-Phenylpropane-2-imines and its derivatives substituted in a benzene ring were synthesized in reaction of proper ketones with ammonia.The keto-enol and imine-enamine tautomerisms in starting compounds and reaction products, respectively, were examined by proton nuclear magnetic resonance spectrometry and chemical methods.The determined constants of tautomeric equilibria were correlated with the Hammett ? constants.Electronic effects occurring in the systems under study were discussed basing on the correlations found.A possible use of 1-phenylpropane-2-imines in synthesis of N-acyl derivatives of 2-phenyl-1-methylvinylamines was examined.
