1443977-74-9

Basic information

• Product Name: 1-(4-fluorobenzyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole
• Synonyms: 1-(4-fluorobenzyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole
• CAS NO: 1443977-74-9
• Molecular Weight: 283.305
• Mol File: 1443977-74-9.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorobenzyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorobenzyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole(1443977-74-9)
• EPA Substance Registry System: 1-(4-fluorobenzyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole(1443977-74-9)

Safety Data

• Hazardous Substances Data: 1443977-74-9(Hazardous Substances Data)

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 159979-96-1 4-fluorobenzyl azide 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 459-46-1 4-Fluorobenzyl bromide 

Relevant articles and documents

Copper (II) immobilized on aminated poly(vinyl chloride) as an efficient and retrievable catalyst for the CuAAC reaction in water under mild conditions

Ethylenediamine functionalized poly(vinyl chloride) (PVC–EDA) was conveniently synthesized by treatment of commercially available PVC powder with ethylenediamine solution. This amine-functionalized PVC was subsequently immersed in copper sulfate solution to form the supported copper catalyst [PVC–EDA–Cu(II)]. The as-prepared catalyst was well characterized with FT–IR, SEM, DSC, TGA, and ICP methods. It was found to catalyze efficiently the CuAAC reaction for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles from benzyl halides, phenylacetylenes, and sodium azide in the presence of sodium ascorbate in water to give the corresponding products under mild and environmentally benign conditions. Various benzyl halides containing electron-withdrawing groups and electron-donating groups afforded the desired products in up to 98% yield. The present procedure has the merits of short reaction time and simple reaction work-up. Moreover, this catalyst can be recovered by simple filtration and reused for at least five consecutive runs without any loss of its catalytic activity.

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The naturally occurring α-chitin biopolymer was employed for the immobilisation of copper(I) ion, resulting into a new bioconjugate complex, namely, Cu(I)-α-chitin (CuI-CHT) with catalytic efficiency in copper-catalysed azide–alkyne cycloaddition reaction

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Loading hyperbranched polyethylenimine (PEI) with copper(II) ions leads to the formation of a new water-soluble metallodendritic polymer Cu(II)-PEI that has been found to effectively catalyze the clickable azide-alkyne [3 + 2] cycloaddition reactions in w

Heterothiometallic clusters as robust and efficient copper(I) catalysts for azide-alkyne [3 + 2] cycloadditions

We investigated heterothiometallic W(Mo)/S/Cu clusters [NH4]2[MS4CunXn] (M = W, Mo; X = Br, I; n = 2, 4, 6) as novel copper(I) catalysts for Huisgen 1,3-dipolar cycloadditions. The experiments indicat

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Copper sulfate has been immobilized over chitosan by simply stirring an aqueous suspension of chitosan in water with copper sulfate; the ensuing catalyst has been utilized for the azide-alkyne cycloaddition in aqueous media and it can be recycled and reus