1443991-56-7

Basic information

• Product Name: 3-phenyl-4-butyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide
• Synonyms: 3-phenyl-4-butyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide
• CAS NO: 1443991-56-7
• Molecular Weight: 342.375
• Mol File: 1443991-56-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-phenyl-4-butyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-4-butyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide(1443991-56-7)
• EPA Substance Registry System: 3-phenyl-4-butyl-1-ethoxy-6-iodobenz[c-1,2]oxaphosphinine 1-oxide(1443991-56-7)

Safety Data

• Hazardous Substances Data: 1443991-56-7(Hazardous Substances Data)

Upstream product

• 4546-19-4 ethyl hydrogen phenylphosphonate 
• 180071-98-1 1-(p-tolyl)-1-hexyne 
• 1754-49-0 diethyl phenylphosphonate 
• 1129-65-3 (hex-1-yn-1-yl)benzene 

Relevant articles and documents

Rhodium-catalyzed oxidative C-H activation/cyclization for the synthesis of phosphaisocoumarins and phosphorous 2-pyrones

Rhodium-catalyzed cyclization of phosphinic acids and phosphonic monoesters with alkynes has been developed. The oxidative annulation proceeds with complete conversion of phosphinic acid derivatives and allowed the atom-economic preparation of useful phosphaisocoumarins with high yield and selectivity. The reaction is tolerant of extensive substitution on the phosphinic acid, phosphonic monoester and alkyne, including halides, ketone, and hydroxyl groups as substituents. Furthermore, we found that alkenylphosphonic monoesters proceed to give a wide range of phosphorus 2-pyrones through oxidative annulation with alkynes. Mechanistic studies revealed that Ci￡H bond metalation was the rate-limiting step. Copyright