1444002-63-4

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 600-00-0 ethyl 2-bromoisobutyrate 
• 29884-24-0 ethyl 2-methyl-2-(4-acetylphenyl)oxypropionate 
• 1257865-15-8 5-(sec-butyl)-4-hydroxybenzene-1,3-dicarbaldehyde 
• 89-72-5 2-sec-butylphenol 

Downstream Products

• 1444002-85-0 (E)-8-sec-butyl-6-(3-(4-(2-carboxypropan-2-yloxy)phenyl)-3-oxoprop-1-enyl)-2-oxo-2H-chromene-3-carboxylic acid 
• 1444002-78-1 (E)-ethyl 8-sec-butyl-6-(3-(4-(1-ethoxy-2-methyl-1-oxopropan-2-yloxy)phenyl)-3-oxoprop-1-enyl)-2-oxo-2H-chromene-3-carboxylate 

Relevant academic research and scientific papers

Coumarin chalcone fibrates: A new structural class of lipid lowering agents

In our continuing search for safe and efficacious antidyslipidemic agents, structurally interesting coumarin-chalcone fibrates were synthesized and evaluated in triton WR-1339 induced hyperlipidemic rats. The most active compound 41 decreased the total cholesterol (TC), phospholipids (PL) and triglycerides (TG), of hyperlipidemic rats by 26, 24, and 25% respectively. In addition, the compound 41 significantly reversed the levels of VLDL, LDL HDL and also increased the LPL activity. Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia.