144403-11-2Relevant academic research and scientific papers
Fragmentation reactions of thiourea- and urea-compounds examined by tandem MS-, energy-resolved CID experiments, and theory
Falvo, Francesco,Fiebig, Lukas,Dreiocker, Frank,Wang, Ran,Armentrout,Sch?fer, Mathias
, p. 124 - 133 (2013/02/23)
Fragmentation reactions of thiourea- and urea-compounds, which are promising reagents for chemical crosslinking (XL), are investigated in detail by collision-induced dissociation (CID) experiments in a quadrupole ion trap (QIT), energy-resolved CID experi
Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains
Ma, Shutao,Jiao, Bo,Ju, Yongjing,Zheng, Manjie,Ma, Ruixin,Liu, Lin,Zhang, Ling,Shen, Xuecui,Ma, Chenchen,Meng, Ya,Wang, Hui,Qi, Yunkun,Ma, Xiaodong,Cui, Wenping
, p. 556 - 566 (2011/03/20)
Novel clarithromycin derivatives with C-4″ elongated arylalkyl groups were designed, synthesized and evaluated to probe the effect of different lengths of their C-4″ side chains on the activity against resistant bacterial strains. These derivatives had excellent activity against erythromycin-susceptible Streptococcus pneumoniae, Streptococcus aureus or Streptococcus pyogenes and some of them exhibited greatly improved activity against erythromycin-resistant strains. Compounds 18 and 16, which had the C-4″ elongated arylalkyl groups with eight atoms from the 4″-oxygen atom to the terminal benzene ring, were the most effective against S. pneumoniae expressing the erm gene and the erm and mef genes. In contrast, the most potent compounds 3, 5, 9, 17 and 18 against S. pneumoniae expressing the mef gene had C-4″ elongated arylalkyl groups with three to eight atoms between the 4″-oxygen atom and the terminal aromatic ring.
A new powerful method for the transformation of lactams into ω-amino-carboxamides under high pressure conditions
Kotsuki,Iwasaki,Nishizawa
, p. 4945 - 4948 (2007/10/02)
High-pressure reaction of N-Boc-lactams with amines provides an efficient entry to ω-N-Boc-aminocarboxamide derivatives.
