144409-99-4

Basic information

• Product Name: AMYLOID BETA-PROTEIN (40-1)
• Synonyms: PEPTIDE WITH REVERSED SEQUENCE OF AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE;VVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD;VAL-VAL-GLY-GLY-VAL-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-VAL-ASP-GLU-ALA-PHE-PHE-VAL-LEU-LYS-GLN-HIS-HIS-VAL-GLU-TYR-GLY-SER-ASP-HIS-ARG-PHE-GLU-ALA-ASP TRIFLUOROACETATE;H-VAL-VAL-GLY-GLY-VAL-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-VAL-ASP-GLU-ALA-PHE-PHE-VAL-LEU-LYS-GLN-HIS-HIS-VAL-GLU-TYR-GLY-SER-ASP-HIS-ARG-PHE-GLU-ALA-ASP-OH;BETA-AMYLOID (40-1);AMYLOID BETA-PROTEIN (40-1);AMYLOID BETA-PROTEIN (40-1) TRIFLUOROACETATE;AMYLOID BETA-PROTEIN FRAGMENT 40-1
• CAS NO: 144409-99-4
• Molecular Formula: C194H295N53O58S
• Molecular Weight: 4329.8034
• Product Categories: Alzheimers and Neurodegenerative Disease Research;Amyloid beta Protein Fragments;Amyloid β Protein FragmentsNeuropeptides;Neurodegenerative Disease Peptides;β Amyloid Peptides;peptide
• Mol File: 144409-99-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: AMYLOID BETA-PROTEIN (40-1)(CAS DataBase Reference)
• NIST Chemistry Reference: AMYLOID BETA-PROTEIN (40-1)(144409-99-4)
• EPA Substance Registry System: AMYLOID BETA-PROTEIN (40-1)(144409-99-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 144409-99-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
Amyloid beta-protein (40-1) is used as a target for developing drugs and therapies aimed at preventing or reducing its aggregation and toxicity in Alzheimer's disease. This includes the development of small molecules, antibodies, and other agents that can modulate Aβ40-1 aggregation, clearance, or interaction with neurons.
Used in Diagnostic Applications:
Aβ40-1 can be used as a biomarker for the early diagnosis and monitoring of Alzheimer's disease. Detecting the presence and levels of Aβ40-1 in biological samples, such as cerebrospinal fluid or blood, can help in identifying individuals at risk or in the early stages of the disease.
Used in Neurodegenerative Disease Research:
Amyloid beta-protein (40-1) is used as a model system to study the molecular mechanisms underlying neurodegeneration in Alzheimer's disease and other related disorders. Investigating the structure, aggregation, and toxicity of Aβ40-1 can provide insights into the pathophysiology of these diseases and identify potential therapeutic targets.
Used in Drug Screening and Toxicity Testing:
Aβ40-1 can be employed in high-throughput screening assays to identify compounds with potential neuroprotective or anti-aggregation properties. Additionally, it can be used in toxicity testing to evaluate the safety and efficacy of newly developed drugs and therapies targeting Alzheimer's disease.
Used in Biomarker Development for Alzheimer's Disease:
Amyloid beta-protein (40-1) can be utilized in the development of diagnostic tools and tests that measure its levels in biological samples. These biomarkers can aid in the early detection, prognosis, and monitoring of Alzheimer's disease progression, enabling more timely and effective treatment interventions.