1444124-69-9

Basic information

• Product Name: 16-phenylsulfinylmethylene-19-norpregna-4,16-diene-3,20-dione
• Synonyms: 16-phenylsulfinylmethylene-19-norpregna-4,16-diene-3,20-dione
• CAS NO: 1444124-69-9
• Molecular Weight: 436.615
• Mol File: 1444124-69-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 16-phenylsulfinylmethylene-19-norpregna-4,16-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 16-phenylsulfinylmethylene-19-norpregna-4,16-diene-3,20-dione(1444124-69-9)
• EPA Substance Registry System: 16-phenylsulfinylmethylene-19-norpregna-4,16-diene-3,20-dione(1444124-69-9)

Safety Data

• Hazardous Substances Data: 1444124-69-9(Hazardous Substances Data)

Upstream product

• 4290-66-8 3-ethoxy-16-methylene-19-norandrosta-3,5-dien-17-one 
• 2863-88-9 3-ethoxy-19-nor-3,5-androstadiene-17-one 
• 734-32-7 estra-4-ene-3,17-dione 
• 1444124-67-7 16-methylene-17α-acetyl-17β-hydroxy-19-norandrosta-4-en-3-one 
• 931-59-9 benzenesulfenyl chloride 
• 2556-16-3 3-ethoxy-16-methylene-17α-ethynyl-17β-hydroxy-19-norandrosta-3,5-diene 
• 1444124-71-3 3-ethoxy-16-methylene-17α-trimethylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene 

Relevant articles and documents

PROCESS FOR ALKYNYLATING 16-SUBSTITUTED-17-KETO STEROIDS

The invention relates to a process for ethynylating 16-methylene-17-keto steroids to the corresponding 16-methylene-17α-ethynyl-17β-hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone? or melengestrol acetate.