144434-75-3Relevant academic research and scientific papers
Synthesis and isolation of bromo-β-carbolines obtained by bromination of β-carboline alkaloids
Ponce,Erra-Balsells
, p. 1087 - 1095 (2007/10/03)
β-Carbolines (1-5) undergo electrophilic aromatic substitution with N-bromosuccinimide under different experimental conditions. Although 6-bromo-nor-harmane (1a) obtained by bromination of nor-harmane (1) was isolated and fully characterized sometime ago,
A new method for bromination of carbazoles, β-carbolines and iminodibenzyls by use of N-bromosuccinimide and silica gel
Smith, Keith,Martin James,Mistry, Anil G.,Bye, Martin R.,John Faulkner
, p. 7479 - 7488 (2007/10/02)
Carbazole, N-ethylcarbazole, iminodibenzyl (10,11-dihydro-5H-dibenz[b,f]azepine), N-ethyliminodibenzyl and imipramine are readily mono-, di- or polybrominated in high yields at ambient temperature in dichloromethane by use of the appropriate quantity of N-bromosuccinimide in the presence of silica gel. By contrast, the brominations of the β-carbolines, harmane and norharman, are less selective and give mixtures of products, some of which have unusual substitution patterns.
