144448-75-9Relevant academic research and scientific papers
Imidazopyridazines. XIII. Syntheses and Central Nervous System Activities of Some 2-Benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)-3-methoxy(acylaminomethyl and dimethylaminomethyl)-6-(variously substituted)imidazopyridazines
Barlin, Gordon B.,Davies, Les P.,Ireland, Stephen J.,Zhang, Jiankuo
, p. 1281 - 1300 (2007/10/02)
6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethyl)-2-benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)imidazopyridazines have been prepared and examined for activity in the central nervous system.Of these, 2-benzyl-3-methoxy-6-(3'-methoxybenzylamino)imidazopyridazine (IC50 88 nM) bound most strongly to rat brain membrane.In general, the order of activity for groups at the 2-position was Ph>PhCH2>PhCH2CH2>C6H4Ph-p, 6'-methylnaphthalen-2'-yl, c-C6H11 or But.
