144449-06-9

Basic information

• Product Name: Imidazo[1,2-b]pyridazine, 6-chloro-2-(phenylmethyl)-
• CAS NO: 144449-06-9
• Molecular Formula: C13H10ClN3
• Molecular Weight: 243.695
• Mol File: 144449-06-9.mol

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-b]pyridazine, 6-chloro-2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-b]pyridazine, 6-chloro-2-(phenylmethyl)-(144449-06-9)
• EPA Substance Registry System: Imidazo[1,2-b]pyridazine, 6-chloro-2-(phenylmethyl)-(144449-06-9)

Safety Data

• Hazardous Substances Data: 144449-06-9(Hazardous Substances Data)

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 20772-12-7 1-bromo-3-phenyl-2-propanone 

Downstream Products

• 144449-39-8 3-benzamidomethyl-2-benzyl-6-chloroimidazo<1,2-b>pyridazine 

Relevant articles and documents

Imidazopyridazines. XV. Synthesis and Anxiolytic Activity of Some 3-(Benzamidomethyl and fluorobenzamidomethyl)-6-(fluoro, chloro and methylthio)-2-(4-tolyl and 3,4-methylenedioxyphenyl)imidazopyridazines

Syntheses are reported for some 3-(benzamido- and fluorobenzamido-methyl)-6-(fluoro, chloro and methylthio)-2-(4-methyl-, 4-t-butyl-, 4-cyclohexyl- and 3,4-methylenedioxy-phenyl)imidazopyridazines from the relevant 3-unsubstituted imidazopyr

Imidazopyridazines. XIII. Syntheses and Central Nervous System Activities of Some 2-Benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)-3-methoxy(acylaminomethyl and dimethylaminomethyl)-6-(variously substituted)imidazopyridazines

6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethyl)-2-benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)imidazopyridazines have been prepared and examined for activity in the central nervous system.Of these, 2-benzyl-3-methoxy-6-(3'-methoxybenzylamino)imidazopyridazine (IC50 88 nM) bound most strongly to rat brain membrane.In general, the order of activity for groups at the 2-position was Ph>PhCH2>PhCH2CH2>C6H4Ph-p, 6'-methylnaphthalen-2'-yl, c-C6H11 or But.