1444554-75-9

Basic information

• Product Name: (3S,8R,10R,12R,14R,17S)-17-((S)-2-hydroxy-5-((4-methoxybenzyl)amino)pentan-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
• Synonyms: (3S,8R,10R,12R,14R,17S)-17-((S)-2-hydroxy-5-((4-methoxybenzyl)amino)pentan-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
• CAS NO: 1444554-75-9
• Molecular Weight: 555.842
• Mol File: 1444554-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,8R,10R,12R,14R,17S)-17-((S)-2-hydroxy-5-((4-methoxybenzyl)amino)pentan-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,8R,10R,12R,14R,17S)-17-((S)-2-hydroxy-5-((4-methoxybenzyl)amino)pentan-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol(1444554-75-9)
• EPA Substance Registry System: (3S,8R,10R,12R,14R,17S)-17-((S)-2-hydroxy-5-((4-methoxybenzyl)amino)pentan-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol(1444554-75-9)

Safety Data

• Hazardous Substances Data: 1444554-75-9(Hazardous Substances Data)

Upstream product

• 6892-79-1 protopanaxadiol 
• 2393-23-9 4-methoxy-benzylamine 

Relevant articles and documents

20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs

Novel 20(S)-protopanoxadiol (PPD) analogues were designed, synthesized, and evaluated for the chemosensitizing activity against a multidrug resistant (MDR) cell line (KBvcr) overexpressing P-glycoprotein (P-gp). Structure-activity relationship analysis showed that aromatic substituted aliphatic amine at the 24-positions (groups V) effectively and significantly sensitized P-gp overexpressing multidrug resistant (MDR) cells to anticancer drugs, such as docetaxel (DOC), vincristine (VCR), and adriamycin (ADM). PPD derivatives 12 and 18 showed 1.3-2.6 times more effective reversal ability than verapamil (VER) for DOC and VCR. Importantly, no cytotoxicity was observed by the active PPD analogues (5 μM) against both non-MDR and MDR cells, suggesting that PPD analogues serve as novel lead compounds toward a potent and safe resistance modulator. Moreover, a preliminary mechanism study demonstrated that the chemosensitizing activity of PPD analogues results from inhibition of P-glycoprotein (P-gp) overexpressed in MDR cancer cells.