144456-86-0

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-6-oxo-2-(trifluoromethyl)-, ethyl ester
• Synonyms: Ethyl 5-cyano-6-hydroxy-2-(trifluoromethyl)nicotinate;Ethyl 5-cyano-6-hydroxy-2-(trifluoromethyl)pyridine-3-carboxylate
• CAS NO: 144456-86-0
• Molecular Formula: C₁₀H₇F₃N₂O₃
• Molecular Weight: 260.17
• Mol File: 144456-86-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-6-oxo-2-(trifluoromethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-6-oxo-2-(trifluoromethyl)-, ethyl ester(144456-86-0)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-6-oxo-2-(trifluoromethyl)-, ethyl ester(144456-86-0)

Safety Data

• Hazardous Substances Data: 144456-86-0(Hazardous Substances Data)

Upstream product

• 571-55-1 ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 1310537-02-0 ethyl 5-cyano-6-(4-{[(4-cyanophenyl)amino]carbonyl}piperazin-1-yl)-2-(trifluoro-methyl)nicotinate 

Relevant articles and documents

Synthesis of novel ethyl 2,4-disubstituted 8-(trifluoromethyl)pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine-9-carboxylate derivatives as promising anticancer agents

A series of novel pyrido[2',3':3,4] pyrazolo[1,5-a]pyrimidine derivatives 6–9 were prepared in single step starting from 3-amino-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 5 on reaction with symmetrical and unsymmetrical aliphatic and ar

Synthesis and cardiotonic activity of 2-substituted 5-cyano-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids and their methyl or ethyl esters

The synthesis of ethyl or methyl esters of 5-cyano-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids carrying as 2-substituent a polar group such as CO2C2H5, (CH2)2CO2CH3, (CH2)3CO2C2H5, CH2OCH3, or CF3 group is described. Also 2-[5-cyano-1,6-dihydro-2-(1,1-dimethylethyl)-6-oxo-3-pyridyl]-2-oxoace tic acid and 2,5,6,8-tetrahydro-2,5-dioxo-1H-thiopyrano[3,4-b]pyridine-3-carbonitri le were prepared. Nearly all the above esters gave routinely the corresponding carboxylic acids by alkaline hydrolysis followed by acidification. As milrinone analogues, the above compounds were tested on contractile activity and frequency rate of spontaneously beating atria from reserpine-treated guinea-pigs. 5-Cyano-2-trifuoromethyl-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid and, in a lesser degree, the relative ethyl ester showed an appreciable positive inotropic activity, although inferior to that of milrinone.