1444623-10-2Relevant academic research and scientific papers
Alkene trifluoromethylation coupled with C-C bond formation: Construction of trifluoromethylated carbocycles and heterocycles
Egami, Hiromichi,Shimizu, Ryo,Kawamura, Shintaro,Sodeoka, Mikiko
supporting information, p. 4000 - 4003 (2013/05/22)
The combo pack: Copper-catalyzed trifluoromethylation of alkenes bearing an allylic proton combined with C-C bond formation affords the title compounds in good to high yields (see scheme). The reactions are faster than allylic trifluoromethylation, especially in 1,4-dioxane. A unique 1,6- oxytrifluoromethylation occurred instead of an anticipated seven-membered ring forming carbotrifluoromethylation reaction.
