144465-84-9

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 104-94-9 4-methoxy-aniline 
• 590-86-3 isovaleraldehyde 
• 122845-63-0 N-(4-Methoxyphenyl)-3-methylbutanaldimine 
• 132127-27-6 (1R,2S)-2-phenyl-1-cyclohexyl<(triisopropylsilyl)oxy>acetate 

Downstream Products

• 209110-49-6 (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-4-isobutyl-1-(4-methoxy-phenyl)-azetidin-2-one 
• 119624-39-4 (2R,3S)-3-amino-2-hydroxy-5-methylhexanoic acid hydrochloride 
• 119624-39-4 (S)-3-Amino-(R)-2-hydroxy-5-methylhexanoic acid hydrochloride 
• 209110-69-0 (2S,3R)-3-(Dimethyl-phenyl-silanyloxy)-2-isobutyl-3-methyl-4-oxo-azetidine-1-carboxylic acid tert-butyl ester 
• 209110-54-3 (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-4-isobutyl-1-(4-methoxy-phenyl)-3-methyl-azetidin-2-one 
• 209110-59-8 (3R,4S)-3-(Dimethyl-phenyl-silanyloxy)-4-isobutyl-3-methyl-azetidin-2-one 

Relevant academic research and scientific papers

Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac

Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac

New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method

Highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4-aryl-β-lactams with excellent enantiomeric purity is successfully applied to the asymmetric synthesis of the enantiomerically pure taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenyl-isoserine and its analogs. (3R,4S)-N-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone readily derived from the 3-hydroxy-4-phenyl-β-lactam is coupled with protected baccatin IIIs, followed by deprotection to give optically pure taxol and 10-deacetyl-7,10-bis(Troc)-taxol in good yields. Fully assigned 1H, 13C, and 2D (COSY and HETCOR) NMR spectra of taxol thus synthesized are shown and discussed.

New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.