1444800-49-0Relevant articles and documents
Four Stereoisomers of 2-Aminomethyl-1-cyclopropanecarboxylic Acid: Synthesis and biological evaluation
Oikawa, Masato,Sugeno, Yuka,Tukada, Hideyuki,Takasaki, Yuichi,Takamizawa, Satoshi,Irie, Raku
, p. 1816 - 1823 (2019)
Here, we report a practical method for asymmetric synthesis of cyclopropane-fused GABA analogs. Starting from 2-furaldehyde, the cis-isomer (CAMP) was synthesized over 10 steps; (1)- and (+)-CAMP¢HCl were synthesized by employing d- and l-menth
A synthesis of (-)- cis -2-aminomethylcyclopropanecarboxylic acid [(-)-CAMP]
Oikawa, Masato,Sugeno, Yuka,Ishikawa, Yuichi,Tukada, Hideyuki
, p. 886 - 888 (2013/05/22)
An enantioselective synthesis of (-)-cis-2- aminomethylcyclopropanecarboxylic acid [(-)-CAMP] has been achieved in 2.5% total yield over ten steps starting from 2-furaldehyde. The synthesis features diastereoselective cyclopropane formation via diazene, followed by oxime formation and the reduction, for construction of the γ-aminobutyric acid (GABA) motif. Georg Thieme Verlag Stuttgart · New York.