1444832-51-2

Basic information

• Product Name: MK-8742
• Synonyms: MK-8742;Elbasvir intermediate;Elbasvir-D6
• CAS NO: 1444832-51-2
• Molecular Formula: C49H55N9O7
• Molecular Weight: 882.0171
• Mol File: 1444832-51-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: MK-8742(CAS DataBase Reference)
• NIST Chemistry Reference: MK-8742(1444832-51-2)
• EPA Substance Registry System: MK-8742(1444832-51-2)

Safety Data

• Hazardous Substances Data: 1444832-51-2(Hazardous Substances Data)

Usage

Uses

Elbasvir-d6 is a labelled version of Elbasvir (E501010), a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. Elbasvir Inhibits NS5A, an important viral phosphoprotein.

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Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF ELBASVIR AND ITS SALT THEREOF

The present invention relates to an improved process for the preparation of Elbasvir compound of Formula-I through its novel salt.

PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS

The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Enantioselective synthesis of an HCV NS5a antagonist

A concise, enantioselective synthesis of the HCV NS5a inhibitor MK-8742 (1) is reported. The features of the synthesis include a highly enantioselective transfer hydrogenation of an NH imine and a dynamic diastereoselective transformation. The synthesis of this complex target requires simple starting materials and nine linear steps for completion.