1445009-53-9Relevant academic research and scientific papers
Sodium hydroxide catalyzed N-alkylation of (hetero) aromatic primary amines and N1,C5-dialkylation of 4-phenyl-2-aminothiazoles with benzyl alcohols
Donthiri, Ramachandra Reddy,Pappula, Venkatanarayana,Chandra Mohan, Darapaneni,Gaywala, Hiren H.,Adimurthy, Subbarayappa
, p. 6775 - 6781 (2013/07/26)
In the presence of a catalytic amount of NaOH, the selective N-alkylation of various heteroaromatic primary amines is reported. With 1 equiv of NaOH, N1,C5-dialkylation of 4-phenyl-2-aminothiazoles has been investigated. Reaction of in situ generated aldehyde with amine yields the N-alkylated and N1,C5-dialkylated products through hydride ion transformation from alcohol.
