1445075-76-2Relevant academic research and scientific papers
Preparation of aromatic triazenes and their application in silver-mediated perfluoroalkylation reactions
Hafner, Andreas,Hussal, Christoph,Braese, Stefan
, p. 1448 - 1454 (2014/06/10)
Herein, the syntheses of various functionalized 1,3-diisopropyltriaz-1-enes is described. This simple transformation tolerates a vast number of functional groups (e.g., halides) and allows the syntheses of 1,3-diisopropyltriaz-1-enes starting from commercially available aniline derivatives. These substrates are suitable for a range of silver-mediated perfluoroalkylation reactions. Georg Thieme Verlag Stuttgart New York.
Silver-mediated methoxycarbonyltetrafluoroethylation of arenes
Hafner, Andreas,Feuerstein, Thomas J.,Braese, Stefan
supporting information, p. 3468 - 3471 (2013/07/26)
In the presence of silver(I) fluoride, highly fluorinated olefins react readily under solvent-free conditions with arenes via CH-substitution. This transformation could be used to synthesize various methoxycarbonyltetrafluoroethylated aromatic triazenes and anisoles under high functional group tolerance. The method could be applied to the synthesis of a formal fluorinated bioisostere of the NSAID flurbiprofen. To the best of our knowledge, this is the first example which uses highly fluorinated olefins for the perfluoroalkylation of aromatic substrates.
