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1445137-80-3

(S)-2-(benzyloxycarbonylamino)-2-methylbut-4-enoic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1445137-80-3 Structure

  • Basic information

    1. Product Name: (S)-2-(benzyloxycarbonylamino)-2-methylbut-4-enoic acid
    2. Synonyms:
    3. CAS NO:1445137-80-3
    4. Molecular Formula:
    5. Molecular Weight: 277.32
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1445137-80-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-2-(benzyloxycarbonylamino)-2-methylbut-4-enoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-2-(benzyloxycarbonylamino)-2-methylbut-4-enoic acid(1445137-80-3)
    11. EPA Substance Registry System: (S)-2-(benzyloxycarbonylamino)-2-methylbut-4-enoic acid(1445137-80-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1445137-80-3(Hazardous Substances Data)

1445137-80-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1445137-80-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,5,1,3 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1445137-80:
(9*1)+(8*4)+(7*4)+(6*5)+(5*1)+(4*3)+(3*7)+(2*8)+(1*0)=153
153 % 10 = 3
So 1445137-80-3 is a valid CAS Registry Number.

1445137-80-3Upstream product

1445137-80-3Relevant articles and documents

Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors

Long, Ya-Qiu,Huang, Shao-Xu,Zawahir, Zahrah,Xu, Zhong-Liang,Li, Huiyuan,Sanchez, Tino W.,Zhi, Ying,De Houwer, Stephanie,Christ, Frauke,Debyser, Zeger,Neamati, Nouri

, p. 5601 - 5612 (2013/07/26)

HIV-1 integrase (IN) catalyzes the integration of viral DNA into the host genome, involving several interactions with the viral and cellular proteins. We have previously identified peptide IN inhibitors derived from the α-helical regions along the dimeric interface of HIV-1 IN. Herein, we show that appropriate hydrocarbon stapling of these peptides to stabilize their helical structure remarkably improves the cell permeability, thus allowing inhibition of the HIV-1 replication in cell culture. Furthermore, the stabilized peptides inhibit the interaction of IN with the cellular cofactor LEDGF/p75. Cellular uptake of the stapled peptide was confirmed in four different cell lines using a fluorescein-labeled analogue. Given their enhanced potency and cell permeability, these stapled peptides can serve as not only lead IN inhibitors but also prototypical biochemical probes or nanoneedles for the elucidation of HIV-1 IN dimerization and host cofactor interactions within their native cellular environment.

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